- More Files
Result Data
Result Data
Inhibition of SIRT1 by Sirtinol (IC50= 38 uM).
- Specification
Product Description
SIRT1 Direct Fluorescent Screening Assay Kit provides a fluorescence-based method for screening SIRT1 inhibitors or activators.
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -80°C.
Note
Result Data
- Applications
Functional Study
- Gene Info — SIRT1
Entrez GeneID
23411Gene Name
SIRT1
Gene Alias
SIR2L1
Gene Description
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Omim ID
604479Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000019691|OTTHUMP00000060745|SIR2alpha|sir2-like 1|sirtuin 1|sirtuin type 1
- Interactome
- Disease
- Publication Reference
- Taurine, homotaurine, GABA and hydrophobic amino acids content influences "in vitro" antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae.
Carlos Terriente-Palacios, Susana Rubiño, Maria Hortós, César Peteiro, Massimo Castellari.
Scientific Reports 2022 Dec; 12(1):20832.
Application：Func, Algae, Brown, Green, Red algae.
- Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-κB and activating SIRT1.
Chen C, Ju R, Zhu L, Li J, Chen W, Zhang DC, Ye CY, Guo L.
Naunyn-Schmiedeberg's Archives of Pharmacology 2017 Apr; 390(4):423.
Application：Enzyme, Quant, Mouse, LLC cells.
- Taurine, homotaurine, GABA and hydrophobic amino acids content influences "in vitro" antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae.