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Result Data
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Result Data

Result Data

Inhibition of SIRT1 by Sirtinol (IC50= 38 uM).

  • Specification

    Product Description

    SIRT1 FRET-based Screening Assay Kit provides a fluorescence-based method for screening SIRT1 inhibitors or activators.

    Regulation Status

    For research use only (RUO)

    Storage Instruction

    Store the kit at -80°C.

    Note

    Result Data

  • Applications

    Functional Study

  • Gene Info — SIRT1

    Entrez GeneID

    23411

    Gene Name

    SIRT1

    Gene Alias

    SIR2L1

    Gene Description

    sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

    Omim ID

    604479

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq

    Other Designations

    OTTHUMP00000019691|OTTHUMP00000060745|SIR2alpha|sir2-like 1|sirtuin 1|sirtuin type 1

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