SARS-CoV-2 - Colchicine - Therapeutic Candidates

SARS-CoV-2 - Colchicine - Therapeutic Candidates


Colchicine is an anti-inflammatory drug used in rheumatology and particularly for the treatment of gouty arthritis or gout. Colchicine is also used in the treatment of other pathologies such as chronic atrophic polychondritis or acute pericarditis after failure of aspirin. 
Studies have shown that SARS-CoVs activate NLRP3 inflammasomes, intracytoplasmic particles that stimulate the release of pro-inflammatory cytokines. In particular, colchicine is believed to inhibit the assembly of the NLRP3 inflammasome and thus the release of cytokines, in particular interleukin-1 beta and interleukin-6. Colchicine is believed to inhibit certain functions of the inflammasome, a component of the immune system that plays a role in triggering cytokine shock and the associated inflammatory cascade. Targeting the inflammatory response with colchicine may therefore reduce complications related to Covid-19 in adults at risk or with signs of inflammatory storm. Three studies are currently underway to investigate the effects of colchicine on Covid-19, the largest, called COLCORONA, involves 6000 patients in Canada.

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Description
Cond.
Price Bef. VAT
C2026-100ML
 100ML 
HY-16569-1ml
 10mM/1mL 
77120.02
 1G 
orb546033-2g
 2g 
orb1904952-2000mg
 2000mg 
orb546033-500mg
 500mg 
orb557496-1g
 1g 
orb1904953-1000mg
 1000mg 
orb1728627-1000mg
 1000mg 
orb1310726-100mg
 100mg 
orb1224352-50mg
 50mg 
orb746388-250mg
 250mg 
orb1310726-500mg
 500mg 
orb1224352-200mg
 200mg 
orb1480468-20mg
 20mg 
orb1224352-100mg
 100mg 
orb1310726-50mg
 50mg 
orb1310726-200mg
 200mg 
orb746388-100mg
 100mg 
orb746388-1g
 1g