FlexISH® probe for detecting rearrangements on BCL2 and BCL6

FlexISH® probe for detecting rearrangements on BCL2 and BCL6

Bringing flexibility to your FISH with FlexISH®


What is a FlexISH® protocol ?
  • FlexISH® maximises your flexibility in terms of time and laboratory management. Hybridisation time can be varied between 2 hours and overnight.
  • With a hybridisation temperature of 37°C the FlexISH® protocol is fully compatible with routine workflows in pathology laboratories



The FlexISH ® BCL2/BCL6 DistinguISH Probe is designed to detect rearrangements involving the chromosomal regions 18q21.33 and 3q27.3 harboring the BCL2 (B-Cell CLL/Lymphoma 2, a.k.a. PPP1R50) gene and the BCL6 (B-Cell CLL/ Lymphoma 6, a.k.a. ZNF51, LAZ3) gene, respectively. Using this probe, it is possible to simultaneously detect BCL2 and/or BCL6 rearrangements commonly found in double-hit lymphoma (DHL) or triple-hit lymphoma (THL).


DLBCL tissue with BCL2/BCL6 co-rearrangement


Product code
Description
Size
   
   
Z-2283-50                         

FlexISH® BCL2/BCL6 DistinguISH                     
5 (50µl)                              
   
Z-2283-200     
   
20 (200µl)
    
   

Other FlexISH® products

Product code
Description
Size
   
   
Z-2166-50                          

FlexISH® ERBB2/CEN 17 Dual Color Probe                   
5 (50µl)                              
   
Z-2166-200     
   
20 (200µl)
    
   
Z-2203-50                         

FlexISH® ALK/ROS1 DistinguISHTM Probe                    
5 (50µl)                              
   
Z-2203-200     
   
20 (200µl)
    
   
Z-2182-5                            

FlexISH-Tissue Implementation kit                     
5                                            
   
Z-2182-20     
   
20