New FISH probe set for glioma diagnostic

New FISH probe set for glioma diagnostic

1p36/19q13 Probe Set with ZyBlack Quenching Solution

ZytoLight® Glioma 1p/19q Probe Set

Deletions affecting the short arm of chromosome 1 (1p36) and the long arm of chromosome 19 (19q13) arefrequently found in human gliomas and are associated with a better survival. The new ZytoLight ® Glioma 1p/19q Probe Set includes FISH probes for the detection of both 1p36 and 19q13 loci and the innovative ZyBlack Quenching Solution.

1p36 Deletion
SPEC 1p36/1q25 Dual Color Probe hybridized to a glioma tissue section with 1p36 deletion as indicated by one orange signal in each nucleus
19q13 Deletion
SPEC 19q13/19p13 Dual Color Probe hybridized to a glioma tissue section with 19q13 deletion as indicated by one orange signal in each nucleus.

Product code Description Components Tests
Z-2272-20 ZytoLight Glioma 1p/19q Probe set
Z-2075-200 20
Z-2076-200
BS-0002-8

ZyBlack Quenching solution permet de réduire l'autofluorescence

Several types of tissue tend to emit intense autofluorescence, including brain, making it difficult to evaluate FISH results. ZyBlack Quenching Solution is a ready-to-use solution that reduces autofluorescence without adversely affecting tissue integrity or specific fluorescence signals. It can be easily incorporated into the FISH protocol by applying it after the proteolytic pretreatment.

Without ZyBlack Quenching Solution With ZyBlack Quenching Solution
Brain tissue section hybridized with the ZytoLight SPEC 1p36/1q25 Dual Color Probe.